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Top 10 sci-tech breakthroughs of China in 2021

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# Study provides target for SARS-CoV-2 antiviral development

A worker weighs chemicals in the lab of a pharmaceutical company in Haikou, Hainan province, Feb. 3, 2020. [Photo/Xinhua]

Researchers from the Chinese Academy of Sciences (CAS), Tsinghua University and ShanghaiTech University presented a structural snapshot of SARS-CoV-2 replication and transcription complex (RTC) as it transitions toward cap structure synthesis. The related findings were published in the journal Cell in November 2020.

Titled "Cryo-EM Structure of an Extended SARS-CoV-2 RTC Reveals an Intermediate State in Cap Synthesis," the paper paves a way to understanding the RTC architecture and provides a target for antiviral development.

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